Signalchem manufactures one of the most comprehensive selections of recombinant Tau proteins. Our selection includes Tau isoforms, phospho-Tau, and mutant variants, which demonstrates SignalChem's drive to provide quality reagents to facilitate research in neurobiology.

Tau is a microtubule-associated protein that interacts with the tubulin subunits, the building blocks of microtubules. Part of the cell’s cytoskeleton network, microtubules play a critical role in the intracellular scaffold and cellular trafficking. Tau is essential for microtubule stabilization, assembly, and function in neuronal morphology and axonal transport. Tau can control microtubule stability by phosphorylation and through the various isoforms of the protein.

Abnormal post-translational modifications of Tau are associated with severe pathogenesis found in multiple neurodegenerative diseases, like Alzheimer’s disease. For example, hyperphosphorylation of Tau leads to the protein’s misfolding and proteinaceous deposits referred to as neurofibrillary tangles (NFT) typically seen in Alzheimer’s. These observations have established Tau proteins as a key therapeutic target and research efforts in understanding Tau’s role in health and disease.