The COVID-19 outbreak due to the novel SARS-CoV-2 virus has turned into a global pandemic infecting hundred thousands of people worldwide. With a rapid rate of infection and a high mortality rate, it is estimated that the novel COVID-19 can infect millions of people all over the globe. Quick intervention at this stage to curb further spread becomes crucial and can only be achieved through expediting critical life science research. Scientists and clinicians around the world are focusing on understanding the molecular biology and mechanisms adapted by COVID-19, and its lethal mode of action. To understand the virus completely and develop safe therapeutic interventions, scientists require a range of trusted molecular biology reagents such as high-quality recombinant proteins related to SARS-CoV-2.
SignalChem, a global leader in cell signaling and protein engineering, has been devoting resources in creating and developing new research tools related to SARS-CoV-2 virus since the outbreak. With the help of advanced bioengineering technology to produce active proteins and AI drug development capability, we have already established expression systems for production of SARS-CoV-2 Spike proteins, RBD fragments, N protein, and other related protein products on a large scale to help detect IgG / IgM in potential patients. These proteins can be used as diagnostic standard antigens and can serve as targets of neutralizing antibodies under development and can also be used by scientists in their development of antibodies to detect SARS-CoV-2 virus in patients. In addition, SignalChem uses mammalian and insect cell expression systems in its production of these protein products as this is more immunogenic than the protein expressed from the E. coli system.
Name | Catalog Number | Lineage | WHO Nomenclature | Assay Types | Species | Tag | Expression System | Sequence | Genbank Number |
2019-nCoV 3CLpro, Active | C19CL-G242H | Activity Assay | 2019-nCoV (virus) | His | E.coli | full-length | QHD43415 | ||
2019-nCoV 3CLpro, Active | C19CL-G241H | Activity Assay | 2019-nCoV (virus) | His | E.coli | full-length | QHD43415 | ||
2019-nCoV NSP10/NSP16 Methyltransferase, Active | C19NS-E301H | Activity Assay | 2019-nCoV (virus) | His | E.coli | heterodimer of full length NSP10 (A4254-Q4392) and NSP16 (S6799-N7096) | QHD43415 | ||
2019-nCoV NSP14 Methyltransferase, Active | C19NS-E311H | ELISA | 2019-nCoV (virus) | His | E.coli | 5925-6452 | QHD43415 | ||
2019-nCoV NSP7 Protein | C19N7-E541H | ELISA | 2019-nCoV (virus) | His | E.coli | full-length | QHD43415 | ||
2019-nCoV NSP8 Protein | C19N8-E541H | ELISA | 2019-nCoV (virus) | His | E.coli | full-length | QHD43415 | ||
2019-nCoV Nucleocapsid (N) Protein | C19NP-G242H | ELISA | 2019-nCoV (virus) | His | E.coli | full-length | QHD43423 | ||
2019-nCoV Nucleocapsid protein CTD | C19ND-G241H | ELISA | 2019-nCoV (virus) | His | E.coli | 237-419 | QHD43423 | ||
2019-nCoV PLpro, Active | C19PL-G241H | Activity Assay, Inhibition Profile | 2019-nCoV (virus) | His | E.coli | full-length | QHD43415 | ||
2019-nCoV RdRp, Active | C19RP-G241H | Activity Assay | 2019-nCoV (virus) | His | E.coli | full-length | QHD43415 | ||
2019-nCoV Spike protein RBD (K417T, E484K, N501Y), HRP conjugated | C19SD-G231AD | P.1 | Gamma | ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with K417T, E484K, N501Y, conjugated to HRP | MN908947 |
2019-nCoV Spike protein RBD (L452R, E484Q), HRP conjugated | C19SD-G231DD | B.1.617.1 | Kappa | ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with L452R, E484Q, conjugated to HRP | MN908947 |
2019-nCoV Spike protein RBD (L452R, T478K), HRP conjugated | C19SD-G231FD | B.1.617.2 | Delta | ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with L452R, T478K, conjugated to HRP | MN908947 |
2019-nCoV Spike protein RBD (R346K, E484K, N501Y) | C19SD-G231NH | Mu Variant | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with R346K, E484K, N501Y | MN908947 | ||
2019-nCoV Spike protein RBD (Y449H, E484K, N501Y) | C19SD-G231PH | C.1.2 | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with Y449H, E484K, N501Y | MN908947 | ||
2019-nCoV spike protein RBD (E484K) | C19SD-G237H | B.1.351 | Beta | ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with E484K | MN908947 |
2019-nCoV Spike protein RBD (E484Q) | C19SD-G231CH | B.1.617.1 | Kappa | ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with E484Q | MN908947 |
2019-nCoV Spike protein RBD (IHU) | C19SD-G231RH | Activity Assay, ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with IHU – R346S, N394S, Y449N, E484K, F490S, N501Y | MN908947 | ||
2019-nCoV Spike protein RBD (K417N) | C19SD-G236H | B.1.351 | Beta | ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with K417N | MN908947 |
2019-nCoV Spike protein RBD (K417N, E484K, N501Y) (Beta variant) | C19SD-G232H | B.1.351 | Beta | ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with K417N, E484K, N501Y | MN908947 |
2019-nCoV Spike protein RBD (K417N, E484K, N501Y), HRP conjugated | C19SD-G232D | B.1.351 | Beta | ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with K417N, E484K, N501Y, conjugated to HRP | MN908947 |
2019-nCoV Spike protein RBD (K417N, L452R, T478K) | C19SD-G231LH | ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with K417N, L452R, T478K | MN908947 | ||
2019-nCoV Spike protein RBD (K417T) | C19SD-G239H | P.1 | Gamma | ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with K417T | MN908947 |
2019-nCoV Spike protein RBD (K417T, E484K and N501Y) | C19SD-G231AH | P.1 | Gamma | ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with K417T, E484K, N501Y | MN908947 |
2019-nCoV Spike protein RBD (L452Q, F490S) | C19SD-G231MH | C.37 | Lambda | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with L452Q, F490S | MN908947 | |
2019-nCoV Spike protein RBD (L452R) | C19SD-G235H | B.1.427/B.1.429 | Epsilon | ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with L452R | MN908947 |
2019-nCoV spike protein RBD (L452R, E484Q) | C19SD-G231DH | B.1.617.1 | Kappa | ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with L452R, E484Q | MN908947 |
2019-nCoV Spike Protein RBD (L452R, T478K) | C19SD-G231FH | AY.4.2 | Delta | ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with L452R T478K | MN908947 |
2019-nCoV Spike protein RBD (N439K) | C19SD-G233H | ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with N439K | MN908947 | ||
2019-nCoV Spike protein RBD (N440K) | C19SD-G231EH | ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with N440K | MN908947 | ||
2019-nCoV Spike protein RBD (N501Y) | C19SD-G231H | B.1.1.7 | Alpha | ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with N501Y | MN908947 |
2019-nCoV Spike protein RBD (N501Y), HRP conjugated | C19SD-G231D | B.1.1.7 | Alpha | ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with N501Y, conjugated to HRP | MN908947 |
2019-nCoV Spike protein RBD (S477G) | C19SD-G231BH | ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with S477G | MN908947 | ||
2019-nCoV Spike protein RBD (S477N) | C19SD-G238H | ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with S477N | MN908947 | ||
2019-nCoV Spike protein RBD (Y453F) | C19SD-G234H | ELISA | 2019-nCoV (virus) | His | CHO cells | RBD (319-541) with Y453F | MN908947 | ||
2019-nCoV Spike protein RBD, HRP conjugated | C19SD-G241D | ELISA | 2019-nCoV (virus) | His | CHO cells | 319-541, conjugated to HRP | MN908947 | ||
2019-nCoV Spike protein RBD, Fc Tag | C19SD-G241F | ELISA, FACS | 2019-nCoV (virus) | Fc | CHO cells | 319-541 | MN908947 | ||
2019-nCoV Spike protein RBD, HIS Tag | C19SD-G241H | ELISA, FACS | 2019-nCoV (virus) | His | CHO cells | 319-541 | MN908947 | ||
2019-nCoV Spike protein S1 (T19R, Δ157-158, L452R, T478K, D614G, P681R) | C19S1-G231FH | B.1.617.2 | Delta | ELISA | 2019-nCoV (virus) | His | CHO cells | S1(16-685) with T19R, ∆157-158, L452R, T478K, D614G, P681R | MN908947 |
2019-nCoV Spike protein S1 (T95I, Y144T, Y145S, ins146N, R346K, E484K, N501Y, D614G, P681H) | C19S1-G231MH | Mu Variant | 2019-nCoV (virus) | His | CHO cells | S1(16-685) with T95I, Y144T, Y145S, ins146N, R346K, E484K, N501Y, D614G, P681H | MN908947 | ||
2019-nCoV Spike protein S1 (Δ69-70, N501Y, D614G) | C19S1-G237H | B.1.1.7 | Alpha | 2019-nCoV (virus) | His | CHO cells | (16-685) with Δ69-70, N501Y, D614G | MN908947 | |
2019-nCoV Spike protein S1 (Δ69-70, Y453F, D614G) | C19S1-G231AH | ELISA | 2019-nCoV (virus) | His | CHO cells | S1(16-685) with Δ69-70, Y453F, D614G | MN908947 | ||
2019-nCoV Spike protein S1 (A222V) | C19S1-G233H | ELISA | 2019-nCoV (virus) | His | CHO cells | (16-685) with A222V | MN908947 | ||
2019-nCoV Spike protein S1 (A222V, D614G) | C19S1-G235H | 2019-nCoV (virus) | His | CHO cells | (16-685) with A222V, D614G | MN908947 | |||
2019-nCoV Spike protein S1 (D614G) | C19S1-G231H | ELISA | 2019-nCoV (virus) | His | CHO cells | S1(16-685) with D614G | MN908947 | ||
2019-nCoV Spike protein S1 (IHU) | C19S1-G231RH | ELISA | 2019-nCoV (virus) | His | CHO cells | S1(16-685) with IHU – E96Q, Δ136-144, R190S, D215H, R346S, N394S, Y449N, E484K, F490S, N501Y, D614G, P681H | MN908947 | ||
2019-nCoV Spike protein S1 (K417N, E484K, N501Y, D614G) | C19S1-G238H | B.1.351 | Beta | ELISA | 2019-nCoV (virus) | His | CHO cells | S1(16-685) with K417N, E484K, N501Y,D614G | MN908947 |
2019-nCoV Spike protein S1 (L452R, E484Q, D614G, P681R) | C19S1-G231EH | 2019-nCoV (virus) | His | CHO cells | (16-685) with L452, E484Q, D614Q, P681R | MN908947 | |||
2019-nCoV Spike protein S1 (N501Y, D614G) | C19S1-G236H | B.1.1.7 | Alpha | ELISA | 2019-nCoV (virus) | His | CHO cells | (16-685) with N501Y, D614G | MN908947 |
2019-nCoV Spike protein S1 (P681H) | C19S1-G232H | B.1.1.7 | Alpha | ELISA | 2019-nCoV (virus) | His | CHO cells | S1(16-685) with P681H | MN908947 |
2019-nCoV Spike protein S1 (T19R, G142D, del157-158, L452R, T478K, D614G, P681R) | C19S1-G231LH | B.1.617.2 | Delta | 2019-nCoV (virus) | His | CHO cells | S1(16-685) with T19R, G142D, ∆157-158,L452R, T478K, D614G, P681R | MN908947 | |
2019-nCoV Spike protein S1 (T95I, G142D, E154K, L452R, E484Q, D614G, P681R) | C19S1-G231KH | B.1.617.1 | Kappa | 2019-nCoV (virus) | His | CHO cells | S1(16-685) with T95I, G142D, E154K, L452R, E484Q, D614G, P681R | MN908947 | |
2019-nCoV Spike protein S1 (Δ69-70 Δ144 N501Y A570D D614G P681H) | C19S1-G239H | B.1.1.7 | Alpha | ELISA | 2019-nCoV (virus) | His | CHO cells | S1(16-685) with Δ69-70 Δ144 N501Y A570D D614G P681H | MN908947 |
2019-nCoV Spike protein S1 (Δ69-70) | C19S1-G234H | B.1.1.7 | Alpha | ELISA | 2019-nCoV (virus) | His | CHO cells | (16-685) with Δ69-70 | MN908947 |
2019-nCoV Spike protein S1 (Δ69-70, N439K, D614G) | C19S1-G231BH | 2019-nCoV (virus) | His | CHO cells | S1(16-685) with Δ69-70, N439K, D614G | MN908947 | |||
2019-nCoV spike protein S1 (ΔY145, ΔH146, E484K, D614G) | C19S1-G231DH | B.1.618 | ELISA | 2019-nCoV (virus) | His | CHO cells | S1(16-685) with ∆Y145, ∆H146, E484K, D614G | MN908947 | |
2019-nCoV Spike protein S1, Fc Tag | C19S1-G241F | FACS | 2019-nCoV (virus) | Fc | CHO cells | 16-685 | MN908947 | ||
2019-nCoV Spike protein S1, HIS Tag | C19S1-G241H | FACS | 2019-nCoV (virus) | His | CHO cells | 16-685 | MN908947 | ||
2019-nCoV Spike protein S2, Fc Tag | C19S2-G241F | ELISA | 2019-nCoV (virus) | Fc | CHO cells | 686-1212 | MN908947 | ||
2019-nCoV Spike RBD-N Protein Chimera | C19NSD-G242H | ELISA | 2019-nCoV (virus) | His | CHO cells | 2019-nCoV’s N-terminal Spike S1 RBD (319-541) fused to Nucleocapsid (237-419) protein with a linker HSA (human serum albumin) | RBD MN908947; N protein QHD43423 | ||
ACE2 (18-739) Protein | A53C2-G341F | ELISA | dog | Fc | CHO cells | 18-739 | XM_014111329 | ||
ACE2 (18-740) Protein | A52C2-G341F | ELISA | rat | Fc | CHO cells | 18-740 | NM_001012006 | ||
ACE2 (19-740) Protein | A51C2-G341F | Activity Assay, ELISA | human | Fc | CHO cells | 19-740 | AF291820 | ||
CD147 (22-205) Protein | C81D7-G651F | ELISA | human | Fc | CHO cells | 22-205 | NM_198589 | ||
CD147 (22-205) Protein | C81D7-G651H | ELISA | human | His | CHO cells | 22-206 | NM_198589 | ||
DPP4 (29-766) Protein | DP4CD-G441H | ELISA | human | His | CHO cells | 29-766 | NM_001935 | ||
MERS Spike Protein RBD | MERSD-G241F | ELISA | MERS-CoV (virus) | Fc | CHO cells | 377-588 | KU696644 | ||
SARS-CoV Spike Protein RBD | SARSD-G241F | ELISA | SARS-CoV (virus) | Fc | CHO cells | 318-510 | AY278554. | ||
SARS-CoV Spike Protein S1, Fc Tag | SARS1-G241F | ELISA | SARS-CoV (virus) | Fc | CHO cells | 14-680 | AY278554. | ||
SARS-CoV Spike Protein S1, HIS Tag | SARS1-G241H | ELISA | SARS-CoV (virus) | His | CHO cells | 14-680 | AY278554. |