概述:

Potent pan-JAK inhibitor, IC50s=1, 20 and 112 nM for JAK3, JAK2, and JAK1 respectively (1). Displays potent anti-inflammatory and immunosuppressant activity (2, 3). Promotes a white-to-brown metabolic conversion in human adipocytes (4). In therapeutic use for rheumatoid arthritis (5).

Genbank编号：

N/A

参考文献：

1. JK Jiang et al. J. Med. Chem. 2008 51:8012. 2. M Cutolo and M Meroni et al. J. Inflamm. Res. 2013 6:129. 3. MN Martina et al. Transplant. Proc. 2016 48:3046. 4. A Moisan et al. Nat. Cell Biol. 2015 17:57. 5. ME Dowty et al. J. Pharmacol. Exp. Ther. 2014 348:165.