概述:

Single-stranded DNA binding protein (SSB) in E. coli is involved in DNA replication, repair, and recombination (1). SSB enhances helix destabilization by DNA helicases thus preventing reannealing of single-stranded DNA and nuclease digestion during DNA replication (1). E. coli SSB is required for methyl-directed mismatch repair, induction of the SOS response, and recombinational repair (1). SSB interacts with DNA helicase RecQ of the RecF-recombination pathway and stimulates helicase activity (2). SSB also stabilizes replication origins, primosome assembly, plays a role in primosome assembly, enhances replication fidelity and polymerase processivity, and promotes polymerase binding to template DNA (1,2).

基因别名：

ssb, exrB, lexC,

Genbank编号：

J01704.1

参考文献：

1. Meyer, R. R., Laine, P. S. The single-stranded DNA-binding protein of Escherichia coli. Microbiol Rev. 1990, 54(4): 342-380. 2. Shereda, R. D. et al. SSB as an organizer/mobilizer of genome maintenance complexes. Crit Rev Biochem Mol Biol. 2008, 43(5): 289-318.